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Regardless of significant binding to plasma proteins (98-99%) - mainly albumin also to a lesser extent α1-acid glycoprotein - diazepam is greatly dispersed into tissues and crosses the blood-brain barrier and is highly lipid soluble, which will cause the initial outcomes to decrease speedily as it truly is redistributed into Unwanted fat deposits
Pacijente treba pažljivo pratiti u cilju prepoznavanja znakova i simptoma respiratorne depresije i sedacije. U ovom pogledu se preporučuje informisanje pacijenata i njihovih staratelja (kada je to primenljivo) o značajnosti prepoznavanja ovih simptoma (videti odeljak 4.five).Despite the fact that scarce, use of acetaminophen has long been claime
Lek Bensedin, rastvor za injekciju/infuziju se koristi za smanjenje anksioznosti i postizanje sedacije kod teške akutne anksioznosti ili agitacije, kao i za terapiju agitacije povezane sa delirium tremens.Postoje naznake da, u slučaju benzodiazepina kratkog dejstva, simptomi obustave mogu da se manifestuju unutar doznog intervala, naročito kada
Hepatic Insufficiency Decreases in clearance and protein binding, and boosts in volume of distribution and 50 %-life are already noted in individuals with cirrhosis. In this sort of patients, a 2- to five-fold increase in signify half-daily life continues to be claimed. Delayed elimination has also been noted for the Energetic metabolite desmethyld